METABOLISM OF MONOAMINES IN MALIGNANT HYPERTHERMIA-SUSCEPTIBLE PIGS
نویسندگان
چکیده
منابع مشابه
Malignant Hyperthermia: Evaluation of “Organon” 9426 in Malignant Hyperthermia Susceptible Pigs
Control pigs required 109.9 ug/kg/min and MHS pigs required 72.4 ug/kg/min infusion of Organon 9426 to maintain a 90% block. It appears that Organon 9426 is only one-third to one-half as potent as Vecuronium in pigs. The fact that MHS pigs only require 66% of the infusion dose to maintain a 90% block suggests that there is difference in the neuromuscular effect of Organon 9426 in MHS vs. contro...
متن کاملEffects of Theophylline on Anesthetized Malignant Hyperthermia-Susceptible Pigs
BACKGROUND Theophylline was shown to induce contracture development in porcine malignant hyperthermia (MH) susceptible (MHS) skeletal muscles in vitro. The purpose of the current study was to investigate the in vivo effects of theophylline in MHS and MH normal (MHN) swine. METHODS MH-trigger-free general anesthesia was performed in MHS and MHN swine. Theophylline was administered intravenousl...
متن کاملIntramuscular injection of sevoflurane detects malignant hyperthermia predisposition in susceptible pigs.
BACKGROUND The authors hypothesized that intramuscular sevoflurane injection allows diagnostic differentiation between malignant hyperthermia-susceptible (MHS) and -nonsusceptible (MHN) pigs by measurement of intramuscular lactate and carbon dioxide partial pressure (PCO2), and that dantrolene reduces the sevoflurane-induced PCO2 increase. METHODS With approval of the local animal care commit...
متن کاملAbnormality in calcium release from skeletal sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia.
Two fractions of sarcoplasmic reticulum, one light (LSR) and one heavy (HSR), were isolated from gracilis muscle of control and malignant hyperthermia (MH)-susceptible pigs. Part of the gracilis muscle biopsy was used to compare the contracture sensitivity of the muscle to the calcium-releasing effects of caffeine on isolated SR membranes. Gracilis muscle of MH pigs was more sensitive to the co...
متن کاملMalignant hyperthermia in Canada: characteristics of index anesthetics in 129 malignant hyperthermia susceptible probands.
BACKGROUND Between 1992 and 2011, 373 Canadian individuals with adverse anesthetic reaction were referred to the Malignant Hyperthermia Unit in Toronto, Ontario, Canada for malignant hyperthermia (MH) diagnostic testing. We analyzed the epidemiologic characteristics of the index adverse anesthetics for those probands who were confirmed to be MH susceptible. METHODS One hundred twenty-nine pro...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1982
ISSN: 0007-0912
DOI: 10.1093/bja/54.12.1313